Computer Aided Biology / Computer Aided Machining Features

Tissue is a complex structure of multiple cell types and extracellular matrix within a dynamic 3d micro-environment. The architecture of tissue is organized through multimeric adhesion complexes that aid in regulating cytoskeletal organization and activate signaling cascades. Numerous biological functions, such as human tissue development, human organs formation, wound healing, and homeostasis, depend on the specific architecture of cells and matrix within a tissue. Now, with the ability to process fragile biomaterials, and assemble them at near cellular levels, nScrypt’s direct print system has the ability to spatially organize both cells and matrix into viable tissue engineered constructs that closely mimic natural tissue. nScrypt's Computer Aided Biology/Computer Aided Machining (CAB/CAM) technology can build precise biological, bioactive, biocompatible, heterogeneous structures with micro-fine detail, all under computer control.

Features of our Computer Aided Biology / Computer Aided Machining Technology

  • Coordinated control of Motion – Dispensing – Sensing
    • Use of a gentle, low temperature process
    • Non-damaging bio-material and substrate handling
    • Bio-friendly patented SmartPump™ direct print micro dispense pump and pen design
    • Full environmental control (humidity, gas, temperature-housed in a BSL 2 system)
    • Minimal effect on materials being deposited
    • No contact with substrate other than deposition material itself
  • Precise start/stop & volume control
  • Structure consistency equivalent to photolithography
  • Geometries as fine as 25 microns
  • Feature thickness (height) as low as 10 micro-meters
  • Positional accuracy of 2 micro-meters
  • Volumetric accuracy to 100 pico-liters
  • Living cells are deposited, undamaged
  • Wide viscosity material handling from 1 centipoise – 1 million centipoise
  • Substrate and deposition material can remain at room temperature or at pre-set temperature
  • Ease of Use
    • Software control of fabrication process
    • No need for templates, masks, screens, etc.
    • Design in CAD (software)
    • Intuitive graphical user interface to build 3D printing on 3D substrates